The Durham difference: considering our context

This article reflects on the experience of Durham University Library staff in promoting services as part of undergraduate induction. It challenges the perception that all methods of marketing are equally valuable to all institutions and explores some alternatives

Chiral SU(3) Dynamics with Coupled Channels: Inclusion of P-Wave Multipoles

We extend our recent non-perturbative chiral SU(3) coupled channel approach to pion- and photon-induced $\eta$- and $K$-meson production off protons by including all strong and electromagnetic p-wave multipoles. We identify the p-wave amplitudes of the next-to-leading order SU(3) chiral meson-baryon Lagrangian with a coupled channel potential which is iterated to infinite orders in a separable Lippmann-Schwinger equation. Our approach to $\eta$- and $K$-photoproduction introduces no additional free parameters. By adjusting a few finite range parameters and the unknown parameters in the Lagrangian, we are able to simultaneously describe a very large amount of low-energy data. These include the total and differential cross sections of the $\pi$-induced reactions $\pi^- p \to \eta n, K^0 \Lambda, K^0 \Sigma^0, K^+ \Sigma^-$ and $\pi^+ p \to K^+ \Sigma^+$ as well as those of photoproduction $\gamma p \to \eta p, K^+\Lambda, K^+ \Sigma^0, K^0 \Sigma^+$. The polarization observables measured in $\eta$- and $K$-photoproduction are particularly sensitive to interference terms between the s- and p-wave multipoles. The total cross section data are remarkably well reproduced in all channels. There remain, however, some open questions concerning details of angular distributions and polarization observables.Comment: 20 pages, 5 figures, accepted for publication in Nucl. Phys.

Tropical Dominating Sets in Vertex-Coloured Graphs

Given a vertex-coloured graph, a dominating set is said to be tropical if every colour of the graph appears at least once in the set. Here, we study minimum tropical dominating sets from structural and algorithmic points of view. First, we prove that the tropical dominating set problem is NP-complete even when restricted to a simple path. Then, we establish upper bounds related to various parameters of the graph such as minimum degree and number of edges. We also give upper bounds for random graphs. Last, we give approximability and inapproximability results for general and restricted classes of graphs, and establish a FPT algorithm for interval graphs.Comment: 19 pages, 4 figure

Perceptual advertisement by the prey of stalking or ambushing predators

There has been previous theoretical explorations of the stability of signals by prey that they have detected a stalking or ambush predator, where such perceptual advertisement dissuades the predator from attacking. Here we use a game theoretical model to extend the theory to consider some empirically-motivated complexities: (i) many perceptual advertisement signals appear to have the potential to vary in intensity, (ii) higher intensity signals are likely to be most costly to produce, and (iii) some high-cost signals (such as staring directly at the predator) can only be utilised if the prey is very confident of the existence of a nearby predator (that is, there are reserved or unfakable signals). We demonstrate that these complexities still allow for stable signalling. However, we do not find solutions where prey use a range of signal intensities to signal different degrees of confidence in the proximity of a predator; with prey simply adopting a binary response of not signalling or always signalling at the same fixed level. However this fixed level will not always be the cheapest possible signal, and we predict that prey that require more certainty about proximity of a predator will use higher-cost signals. The availability of reserved signals does not prohibit the stability of signalling based on lower-cost signals, but we also find circumstances where only the reserved signal is used. We discuss the potential to empirically test our model predictions, and to develop theory further to allow perceptual advertisement to be combined with other signalling functions

A Glycosylphosphatidylinositol Anchor Is Required for Membrane Localization but Dispensable for Cell Wall Association of Chitin Deacetylase 2 in Cryptococcus neoformans

Cell wall proteins (CWPs) mediate important cellular processes in fungi, including adhesion, invasion, biofilm formation, and flocculation. The current model of fungal cell wall organization includes a major class of CWPs covalently bound to β-1,6-glucan via a remnant of a glycosylphosphatidylinositol (GPI) anchor. This model was established by studies of ascomycetes more than a decade ago, and relatively little work has been done with other fungi, although the presumption has been that proteins identified in the cell wall which contain a predicted GPI anchor are covalently linked to cell wall glucans. The pathogenic basidiomycete Cryptococcus neoformans encodes >50 putatively GPI-anchored proteins, some of which have been identified in the cell wall. One of these proteins is chitin deacetylase 2 (Cda2), an enzyme responsible for converting chitin to chitosan, a cell wall polymer recently established as a virulence factor for C. neoformans infection of mammalian hosts. Using a combination of biochemistry, molecular biology, and genetics, we show that Cda2 is GPI anchored to membranes but noncovalently associated with the cell wall by means independent of both its GPI anchor and β-1,6-glucan. We also show that Cda2 produces chitosan when localized to the plasma membrane, but association with the cell wall is not essential for this process, thereby providing insight into the mechanism of chitosan biosynthesis. These results increase our understanding of the surface of C. neoformans and provide models of cell walls likely applicable to other undercharacterized basidiomycete pathogenic fungi

Macrophages sustain HIV replication in vivo independently of T cells

Macrophages have long been considered to contribute to HIV infection of the CNS; however, a recent study has contradicted this early work and suggests that myeloid cells are not an in vivo source of virus production. Here, we addressed the role of macrophages in HIV infection by first analyzing monocytes isolated from viremic patients and patients undergoing antiretroviral treatment. We were unable to find viral DNA or viral outgrowth in monocytes isolated from peripheral blood. To determine whether tissue macrophages are productively infected, we used 3 different but complementary humanized mouse models. Two of these models (bone marrow/liver/thymus [BLT] mice and T cell–only mice [ToM]) have been previously described, and the third model was generated by reconstituting immunodeficient mice with human CD34+ hematopoietic stem cells that were devoid of human T cells (myeloid-only mice [MoM]) to specifically evaluate HIV replication in this population. Using MoM, we demonstrated that macrophages can sustain HIV replication in the absence of T cells; HIV-infected macrophages are distributed in various tissues including the brain; replication-competent virus can be rescued ex vivo from infected macrophages; and infected macrophages can establish de novo infection. Together, these results demonstrate that macrophages represent a genuine target for HIV infection in vivo that can sustain and transmit infection

Mixed effects of long-term conservation investment in Natura 2000 farmland

Evaluating the effectiveness of conservation funding is crucial for correct allocation of limited resources. Here we used bird monitoring data to assess the effects of long-term conservation investment in a Natura 2000 (N2000) bird protection area (PA), which during two decades benefited from protection regulations, conservation projects, and agri-environment schemes. Variation between 1995–1997 and 2010–2012 in richness and abundance of flagship (Otis tarda, Tetrax tetrax, and Falco naumanni) and specialized fallow field species were more favorable (i.e., increased more or declined less) inside the PA than in a nearby control area. However, the reverse was found for total bird species, farmland, ground-nesting and steppe species, species associated to ploughed fields, and species of European conservation concern. Enhancing the effectiveness of conservation investment in N2000 farmland may require a greater focus on the wider biodiversity alongside that currently devoted to flagship species, as well as improved matching between conservation and agricultural policies.info:eu-repo/semantics/publishedVersio

The social value of a QALY : raising the bar or barring the raise?

Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England, there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether QALYs gained by different beneficiaries of health care should be weighted equally. The Social Value of a QALY (SVQ) project, reported in this paper, was commissioned to address these two questions. The results of SVQ were released during a time of considerable debate about the NICE threshold, and authors with differing perspectives have drawn on the SVQ results to support their cases. As these discussions continue, and given the selective use of results by those involved, it is important, therefore, not only to present a summary overview of SVQ, but also for those who conducted the research to contribute to the debate as to its implications for NICE. Discussion: The issue of the threshold was addressed in two ways: first, by combining, via a set of models, the current UK Value of a Prevented Fatality (used in transport policy) with data on fatality age, life expectancy and age-related quality of life; and, second, via a survey designed to test the feasibility of combining respondents’ answers to willingness to pay and health state utility questions to arrive at values of a QALY. Modelling resulted in values of £10,000-£70,000 per QALY. Via survey research, most methods of aggregating the data resulted in values of a QALY of £18,000-£40,000, although others resulted in implausibly high values. An additional survey, addressing the issue of weighting QALYs, used two methods, one indicating that QALYs should not be weighted and the other that greater weight could be given to QALYs gained by some groups. Summary: Although we conducted only a feasibility study and a modelling exercise, neither present compelling evidence for moving the NICE threshold up or down. Some preliminary evidence would indicate it could be moved up for some types of QALY and down for others. While many members of the public appear to be open to the possibility of using somewhat different QALY weights for different groups of beneficiaries, we do not yet have any secure evidence base for introducing such a system

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target

Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment. Metabolic features of these cells are being studied in deep in order to find relationships between metabolism within the tumor microenvironment and tumor progression. Moreover, it cannot be forgotten that tumor growth is able to modulate host metabolism and homeostasis, so that tumor microenvironment is not the whole story. Importantly, the metabolic switch in cancer is just a consequence of the flexibility and adaptability of metabolism and should not be surprising. Treatments of cancer patients with combined therapies including anti-tumor agents with those targeting stromal cell metabolism, anti-angiogenic drugs and/or immunotherapy are being developed as promising therapeutics.Mª Carmen Ocaña is recipient of a predoctoral FPU grant from the Spanish Ministry of Education, Culture and Sport. Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript

Constitutivism

A brief explanation and overview of constitutivism